北京中医药大学学报2012，Vol.35Issue(7)：484-489,6.
益智亲水凝胶骨架片体外释放度的研究
Release rate in vitro of Yizhi hydrogel matrix tablets
摘要
Abstract
Objective To establish a method for determining the release rate in vitro of Yizhi hydrogel matrix tablets, investigate the influence factors and study the mechanism of release in vitro. Methods The matrix tablets were prepared by using the methods of powder direct compression taken hydroxypropyl methylcellulose ( HPMC) K15M and K4M as the matrix material, and geniposide, notoginsenoside R,, ginsenoside Rg, and ginsenoside Bb1 as review indexes. The release rate in vitro of the matrix tablets was investigated in different detection methods, dissolution media and rotating speed. The difference of release was reviewed by using similarity factor f2 method, release equation was fitted and release mechanism was studied. Results Different detection methods, dissolution media and rotating speed had influences on the release rate in vitro of the matrix tablets. The mechanism was accorded with zero-order kinetic equation and Ritger-Peppas equation. Geniposide released in the way of non-Fick diffusion and notoginsenoside R1, ginsenoside Rg, and ginsenoside Rbt in the way of bulk erosion. Conclusion The method for determining the release rate in vitro of Yizhi hydrogel matrix tablets was established and the mechanism is accorded with release kinetic model, which is worth further study.关键词
益智亲水凝胶骨架片/羟丙甲基纤维素/体外释放/三七总皂苷/栀子苷Key words
Yizhi hydrophilic matrix tablets/ hydroxypropyl methylcellulose/ release in vitro/ panax notoginseng saponins/ geniposide分类
医药卫生引用本文复制引用
武慧超,陆洋,杜守颖,翟永松,蔡程博,赵静宜..益智亲水凝胶骨架片体外释放度的研究[J].北京中医药大学学报,2012,35(7):484-489,6.基金项目
“重大新药创制”科技重大专项(No.2009ZX09502-008,No.2009ZX09308-003),国家自然科学基金项目(No.81073057),北京中医药大学自主选题项目(No.JYBZZ-XS036),北京中医药大学创新团队发展计划资助项目(No.2011-CXTD-13) （No.2009ZX09502-008,No.2009ZX09308-003）
