大连工业大学学报2012，Vol.31Issue(5)：326-329,4.
紫杉醇硅胶表面分子印迹纳米颗粒的制备
Preparation of paclitaxel molecularly imprinted silica nanoparticles
摘要
Abstract
Paclitaxel templates were imprinted into the silica layer by thermally cleavable urethane bonds between paclitaxel and 3-isocyanatopropyltriethoxysilane (IPTS) , which was synchronously coated onto the surface of silica nanoparticles through a sol-gel processing between paclitaxel-IPTS and tetraethoxysilcane (TEOS). After removal of templates by simple thermal cleavage reaction, the molecularly imprinted layer-coated silica nanoparticles for paclitaxel were synthesized. Afterwards, the paclitaxel imprinted silica nanoparticles were evaluated by rebinding experiments and showed higher affinity to paclitaxel than the non-imprinted silica nanoparticles.关键词
紫杉醇/分子印迹技术/溶胶-凝胶方法/硅胶纳米颗粒Key words
paclitaxel/ molecular imprinting technique/ sol-gel process/ silica nanoparticles分类
轻工纺织引用本文复制引用
付绍平,李建华,朱靖博..紫杉醇硅胶表面分子印迹纳米颗粒的制备[J].大连工业大学学报,2012,31(5):326-329,4.基金项目
辽宁省教育厅科学研究计划资助项目(L2010047 （）
L2010052) （）
中药制药过程新技术国家重点实验室项目(SKL2010M0205 （）
SKL2010Z0201). （）
