动物学研究2012，Vol.33Issue(4)：362-366,5.DOI:10.3724/SP.J.1141.2012.04362
PCDHα在髓鞘形成和少突胶质细胞发育中的作用
Protocadherin α gene cluster is required for myelination and oligodendrocyte development
摘要
Abstract
This work used Imrnunohistochemistry to examine the expression of myelin basic protein and accumulation of oligodendrocytes in Pchda knockout and control littermate mice. Data showed that in Pchda knockout mice, Myelin proteins decrease in the central nervous system and mature oligodendrocytes in the cerebellum also decrease. Furthermore, deletion of the Pcdha cluster does not cause any change to the axons and astrocytes in quantification of relative marker proteins. These findings suggest that the Pcdha cluster may be required for myelination and oligodendrite development of the brain in mice, and that Pcdha cluster may play a key role in the development of the central nervous system.关键词
原钙黏蛋白/髓鞘/少突胶质细胞/发育Key words
Protocadherin/ Myelin/ Oligodendrocyte/ Development分类
生物科学引用本文复制引用
于钰,索伦,吴强..PCDHα在髓鞘形成和少突胶质细胞发育中的作用[J].动物学研究,2012,33(4):362-366,5.基金项目
国家自然科学基金资助项目(31171015) （31171015）
