南方医科大学学报2012，Vol.32Issue(9)：1336-1340,5.DOI:10.3969/j.issn.1673-4254.2012.09.028
基质金属蛋白酶9和基质金属蛋白酶组织抑制剂1,2在子宫剖宫产疤痕中的表达和相关性
Correlation of the expressions of MMPs-9, TIMP-1 and TIMP-2 with cesarean section scar
摘要
Abstract
Objective To investigate the roles of MMPs-9, TIMP-1 and TIMP-2 in cesarean section scar healing. Methods The expressions of the MMPs-9, TIMP-1 and TIMP-2 were detected by EnVision immunohistochemistry in 22 pregnant women with serious complications of the uterine scar, including 8 with early caesarean scar pregnancy (CSP) and 14 with full-term pregnancy undergoing hysterectomy for placenta previa or implanted placenta. Thirty-eight full-term pregnant women without serious complications of the uterine scar and 32 normal full-term pregnant women served as the control I and control II groups, respectively. Results The expressions of MMPs-9 and TIMP-1 differed significantly between the 3 groups (P<0.05), whereas TIMP-2 did not (P>0.05). Spearman rank correlation analysis showed that the expression of MMPs-9 in the uterine scar tissues was positively correlated with poor uterine scar healing with the correlation coefficients of 0.309 and 0.643. An increased severity of poor healing scar was associated with a significantly increased expression of MMPs-9 (P<0.05). Conclusion The imbalanced expressions of MMPs-9 and TIMP-1 in injury repair can be related to poor uterine scar healing and CSP.关键词
剖宫产/疤痕/基质金属蛋白酶9/基质金属蛋白酶组织抑制剂1,2/免疫组织化学Key words
Cesarean section/ scar/ MMPs-9/ TIMP-1/2/ immunohistochemistry分类
医药卫生引用本文复制引用
李琼,郭遂群,柳大烈,冯淑英,魏清柱..基质金属蛋白酶9和基质金属蛋白酶组织抑制剂1,2在子宫剖宫产疤痕中的表达和相关性[J].南方医科大学学报,2012,32(9):1336-1340,5.基金项目
广东省科技计划项目(2008B060600069) （2008B060600069）
