摘要
Abstract
Objective: To observe the clinical effect of montelukast combined with budesonide in bronchiolitis. Methods: Ninety cases of children with capillarybronchitis were randomly divided into the experimental group (48 cases) and the control group (42 cases). 40 healthy children were selected as normal control group. Both the experimental group and the control group were given traditional therapy. The experimental group received montelukast (< 6 months, 2 mg/d; 6-18 months, 4 mg/d, orally at bedtime) and budesonide suspension, 1 mL/time, twice a day till the symptoms were disappeared, then continued to take montelukast for one week. The disappearance time of symptoms and physical signs, the length of hospital stay and the cure rate were compared and analyzed between the two groups. And the changes of IgE, IL-4 and Eos in serum before and after treatment were observed. The difference was compared between the experimental group, the control group and the normal control group. Results: The cure rate of the experimental group was 91. 1% , and that of the control group was 69. 0%. The difference between these two groups was statistically significant (X2 =7.48, P<0. 01). The experimental group was superior to the control group in shortening the length of hospital stay, relieving and shortening the degree and the time of wheezing and coughs. Their differences were statistically significant (P<0. 05). The expression levels of IgE, IL-4 and Eos in serum after treatment were significantly lower than those before treatment (P<0.01) , especially in the experimental group (P<0.05). Conclusions: Combined therapy of montelukast and budesonide used for treatment of capillary bronchitis in children can significantly enhance clinical effect and reduce complications, so it deserved clinical application.关键词
孟鲁司特/布地奈德/毛细支气管炎Key words
Montelukast/Budesonide/Bronchiolitis分类
医药卫生
