儿科药学杂志2012，Vol.18Issue(10)：28-30,3.
丙戊酸钠血药浓度监测及其治疗儿童癫痫224例疗效分析
The Analysis of Serum Concentrations of Valproic Acid of 224 Epileptic Children
陈英才 1文程 2王薇1
作者信息
- 1. 大庆油田总医院,黑龙江大庆163001
- 2. 大庆医学高等专科学校,黑龙江大庆163001
- 折叠
摘要
Abstract
Objective: To provide some, information about rationally administrating valproic acid for epileptic children. Methods: The serum concentrations of valproate sodium of 224 children with epilepsy were monitored by fluorescence polarization immunoassay (FPIA). Results: The concentrations of sodium valproate which were <50 mg/L, 50 ~ 100 mg/L, >100 mg/L accounted for 43 cases (26.22%), 106 cases (64.64%), 15 cases (9. 15%) and the total effective rates were 37.21%, 78.30%, 53.33%. The combination medication of carbamazepine and phenobarbital could decrease the serum concentration of valproic acid. Conclusions: Monitoring of serum concentration of valproic acid is of great importance in rationally administrating valproic acid for epileptic children, and the individual difference of serum concentration is large. It is suggested that an individual administrated scheme should be applied in clinical practice.关键词
丙戊酸钠/血药浓度监测/儿童Key words
Valproic acid/Monitoring of serum concentration/Children分类
医药卫生引用本文复制引用
陈英才,文程,王薇..丙戊酸钠血药浓度监测及其治疗儿童癫痫224例疗效分析[J].儿科药学杂志,2012,18(10):28-30,3.
