癌症（英文版）2012，Vol.31Issue(9)：430-439,10.DOI:10.5732/cjc.011.10454
Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway
Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway
Chuan Wang 1Qiang Chen 1Yuki Hamajima 2Wei Sun 3Yi-Qing Zheng 3Xiao-Hua Hu 1Frank G.Ondrey 4Ji-Zhen Lin1
作者信息
- 1. The Cancer Center and Fujian Key Laboratory of Translational Cancer Medicine, Union Hospital, Fujian Medical University,Fuzhou, Fujian 350001, P. R. China
- 2. Department of Otolaryngology Head and Neck Surgery, University of Nagoya City, Nagoya 460-0002, Japan
- 3. Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, P. R. China
- 4. Department of Otolaryngology and Cancer Center, University of Minnesota, Minneapolis,MN 55455, USA
- 折叠
摘要
Abstract
Squamous cell carcinoma (SCC) is a significant cause of cancer morbidity and mortality worldwide,with an incidence of up to 166 cases per 100 000 population.It arises in the skin,upper aerodigestive tract,lung,and cervix and affects more than 200 000 Americans each year.We report here that a microarray experiment comparing 41 SCC and 13 normal tissue specimens showed that Id2,a gene that controls the cell cycle,was significantly up-regulated in SCC.Enforced expression of Id2 in vitro stimulated the proliferation of SCC cells and up-regulated the transcription of nuclear factor kappa B (NF-κB) and cyclin D1.Enhancement of the NF-κB activity with p65 significantly increased the cell proliferation and the transcription of cyclin D1,whereas inhibition of the NF-κB activity with I kappa B alpha mutant (IκBα M) and pyrroline dithiocarbamate (PDTC) abrogated cell proliferation and transcription of cyclin D1.Furthermore,a mutated NF-κB binding site in the cyclin D1 promoter fully abrogated the Id2- induced transcription of cyclin D1.Taken together,these data indicate that Id2 induces SCC tumor growth and proliferation through the NF-κB/cyclin D1 pathway.关键词
Id2/head and neck squamous cell carcinoma/NF-κB/cyclin D1/humanKey words
Id2/head and neck squamous cell carcinoma/NF-κB/cyclin D1/human引用本文复制引用
Chuan Wang,Qiang Chen,Yuki Hamajima,Wei Sun,Yi-Qing Zheng,Xiao-Hua Hu,Frank G.Ondrey,Ji-Zhen Lin..Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway[J].癌症（英文版）,2012,31(9):430-439,10.
