癌症（英文版）2012，Vol.31Issue(11)：507-518,12.DOI:10.5732/cjc.011.10377
Chemical proteomics: terra incognita for novel drug target profiling
Chemical proteomics: terra incognita for novel drug target profiling
摘要
Abstract
The growing demand for new therapeutic strategies in the medical and pharmaceutic fields has resulted in a pressing need for novel druggable targets.Paradoxically,however,the targets of certain drugs that are already widely used in clinical practice have largely not been annotated.Because the pharmacologic effects of a drug can only be appreciated when its interactions with cellular components are clearly delineated,an integrated deconvolution of drug-target interactions for each drug is necessary.The emerging field of chemical proteomics represents a powerful mass spectrometry (MS)-based affinity chromatography approach for identifying proteome-wide small molecule-protein interactions and mapping these interactions to signaling and metabolic pathways.This technique could comprehensively characterize drug targets,profile the toxicity of known drugs,and identify possible off-target activities.With the use of this technique,candidate drug molecules could be optimized,and predictable side effects might consequently be avoided.Herein,we provide a holistic overview of the major chemical proteomic approaches and highlight recent advances in this area as well as its potential applications in drug discovery.关键词
Chemical proteomics/drug target profilingKey words
Chemical proteomics/drug target profiling引用本文复制引用
Fuqiang Huang,Boya Zhang,Shengtao Zhou,Xia Zhao,Ce Bian,Yuquan Wei..Chemical proteomics: terra incognita for novel drug target profiling[J].癌症（英文版）,2012,31(11):507-518,12.基金项目
This work was supported by grants from the National Basic Research Program of China (No.2011CB910703),the National 863 High Tech Foundation (No.2007AA021205),and Chinese NSFC (No.81072022). （No.2011CB910703）
