高等学校化学学报2012，Vol.33Issue(8)：1745-1750,6.DOI:10.3969/j.issn.0251-0790.2012.08.021
新型不对称草酰二胺类化合物的设计、合成及生物活性
Design, Synthesis and Biological Activities of Novel Ortho-dicarboxyamides
摘要
Abstract
In order to look for novel potential active pesticides, a series of ortho-dicarboxyamides developed from structures of chlorantraniliprole and fipronil, were designed and synthesized according to the bio-rational design principle. Their structures were characterized by 1H NMR and HRMS. The preliminary results of biological experiments indicated that the title compounds exhibited unsatisfactory insecticidal activities against Mythimna separata Walker at 200 mg/L, however, at 50 mg/L, compounds 6e and 6f exhibited a fungicidal activity of 45. 0% against Alternaria solani which is higher than the other compounds. The results indicated that the compounds contained 2,4,6-trichlorobenzene group showed the best fungicidal activities against Alternaria solani; compound 6g exhibited a fungicidal activity of 51. 9% against Physalospora piricola which is better than the other compounds. The results indicated that the compounds contained the larger steric group showed the excellent fungicidal activities against Physalospora piricola.关键词
氯虫酰胺/氟虫腈/草酰二胺/杀虫活性/抑菌活性Key words
Chlorantraniliprole/ Fipronil/ Dicarboxyamide/ Insecticidal activity/ Fungicidal activity分类
化学化工引用本文复制引用
闫涛,刘鹏飞,张吉凤,于淑晶,熊丽霞,李正名..新型不对称草酰二胺类化合物的设计、合成及生物活性[J].高等学校化学学报,2012,33(8):1745-1750,6.基金项目
国家“九七三”计划项目(批准号:2010CB126106)和国家自然科学基金(批准号:20872069)资助. （批准号:2010CB126106）
