肝胆胰外科杂志2012，Vol.24Issue(5)：386-389,4.
AP-1和MMP-9蛋白在肝细胞癌组织中的表达及临床意义
Expression and clinical signficance of AP-1 and MMP-9 protein in hepatocellular carcinoma tissues
法镇中 1江勇 2汤建军 1严国度1
作者信息
- 1. 江苏大学附属武进医院 肝胆外科,江苏 常州 213002
- 2. 苏州大学附属第三医院 肝胆外科,江苏 常州 213003
- 折叠
摘要
Abstract
Objective To investigate the expression characteristics, interrelationships and clinical significance of activating protein-1 (AP-1) and matrix metalloproteinase-9 (MMP~-) in hepatocellular carcinoma (HCC) tissues. Methods The expression of AP-1 and MMP-9 protein as detected with immunohistochemical ( SABC ) analysis were compared in 56 cases of HCC Correlations of the expression of AP-l/MMP-9 to clinicopathologic features were analyzed. Results The positive expression rates of APM (c-Jun/c-Fos) and MMP-9 protein in HCC were significantly higber than that in pericarcinoma tissues (P<0.01). The expression of AP-1 (c-Jun/c-Fos) was positively related to introhepatic metasrasis, pathology grade and TNM stage (P<0. 05 or P<0.01). The expression of MMP-9 was related to introhepatic metascasis, tumor capsule and TNM stage (P<0.05 or P<0.01). The expression of MMP-9 was positively correlated with AP-1 (c-Jun/c-Fos) in HCC tissues( r= 0.535, P<0.01), Conclusion The expression of AP-1 and MMP-9 protein may play vital roles in the earcinogenesis and development of HCC. AP-1 may he through up-regulation of MMP-9 expression and activity to promote invasion and metastasis of HCC,
关键词
转录因子激活蛋白-1/基质金属蛋白酶-9/癌,肝细胞Key words
activating protein-1 (AP-l)/ matrix metalloproteinases-9 (MMP-9)/ carcinoma, hepatocellular (HCC)分类
医药卫生引用本文复制引用
法镇中,江勇,汤建军,严国度..AP-1和MMP-9蛋白在肝细胞癌组织中的表达及临床意义[J].肝胆胰外科杂志,2012,24(5):386-389,4.
