国际医药卫生导报2012，Vol.18Issue(19)：2862-2865,4.DOI:10.3760/cma.j.issn.1007-1245.2012.19.026
无创正压通气联合辛伐他汀治疗COPD合并Ⅱ型呼吸衰竭的疗效观察
The efficacy of noninvasive positive pressure ventilation combined with simvastatin for COPD with type Ⅱ respiratory failure
摘要
Abstract
Objective To investigate the clinical efficacy of noninvasive positive pressure ventilation ( NIPPV ) combined with simvastatin in the treatment of COPD with type Ⅱ respiratory failure.Methods 106 COPD patients with type Ⅱ respiratory failure were randomly divided into two groups.The control group ( 53 patients ) received conventional medical treatment and NIPPV,while the study group ( 53 patients )received simvastatin in addition to the therapies used in the control group.The clinical efficacy and the results of blood gas analysis were compared between the two groups.Results The total effectiveness rate differed significantly between the study group and the control group ( 94.34％ vs.81.13％,P＜ 0.05 ).PH value and PaO2 were significantly increased and PaCO2 was decreased in the two groups 72 h after treatment.As compared with the control group,the indicators of arterial blood gas analysis were improved significantly in the study group ( P＜ 0.05 ).FEV1/FVC and predicted FEV1％ were improved markedly on weeks 12.Indicators of lung function improved more significantly in the study group than in the control group ( P ＜ 0.05 ).Conclusions NIPPV combined with simvastatin for COPD with type Ⅱ respiratory failure is efficacious,safe,and reliable.It can significantly improve respiratory function and is worth popularizing clinically.关键词
无创正压通气/COPD/呼吸衰竭/辛伐他汀Key words
Noninvasive positive pressure ventilation/COPD/Respiratory failure/Simvastatin引用本文复制引用
邹鹏..无创正压通气联合辛伐他汀治疗COPD合并Ⅱ型呼吸衰竭的疗效观察[J].国际医药卫生导报,2012,18(19):2862-2865,4.
