摘要
Abstract
According to its mechanisms of action, gonadotrophin-releasing hormone analogs (GnRH-A) are divided into two categories:agonist and antagonist. It has been demonstrated that 80% of ovarian and endometrial cancers express GnRH and its receptors. The anti-cancer role of GnRH-A is played either by suppressing the hypothalamic-pituitary axis or through its autocrine and paracrine systems. GnRH-A had been used in the treatment of advanced or recurrent endometrial and ovarian cancers, but the effect is no better than other second-line drugs.These days, the application of GnRH-A in the preservation of fertility and ovarian function has become increasingly popular. Besides, the use of GnRH -A in molecular targeted therapy is also promising.关键词
促性腺素释放激素/受体,LHRH/生殖器肿瘤,女(雌)性/治疗/卵巢Key words
Gonadotropin-releasing hormone/Receptors, LHRH/Genital neoplasms, female/Therapy/Ovary
