医学分子生物学杂志2012，Vol.9Issue(3)：221-225,5.DOI:10.3870/j.issn.1672-8009.2012.03.014
间充质干细胞诱导分化为胰岛分泌细胞治疗1型糖尿病
Research Progress of Induction and Differentiation of Mesenchymal Stem Cells to Insulin-Producing Cells For the Treatment of Type 1 Diabetes
胡培 1王小莉 2严世荣3
作者信息
- 1. 武汉大学中南医院,武汉市,443071
- 2. 湖北医药学院附属人民医院检验科,湖北省十堰市,442000
- 3. 湖北医药学院附属太和医院生命科学研究所,湖北省十堰市,442000
- 折叠
摘要
Abstract
Recently , diabetes has been one of the most severe diseases which is threatening to human health. Though hyperglycemia can be effectively reversed by injection of insulin or transplan -tation of islet, these methods have been greatly restricted by several reasons . A body of literatures have demonstrated that MSC can be differentiated into insulin -producing cells in vitro by chemical and biological substance or gene transfection , and the hyperglycemia model of mice with diabetes can be reversed through transplatation. A review on how the insulin-producing cells be induced from different origins of mesenchymal stem cells and the research progress of induction and differentiation of mesenchymal stem cells for the treatment of type 1 diabetes has been described in this paper.关键词
间充质干细胞/诱导分化/胰岛素分泌细胞/1型糖尿病Key words
mesenchymal stem cell/induction and differentiation/insulin-producing cells/type 1 diabetes分类
医药卫生引用本文复制引用
胡培,王小莉,严世荣..间充质干细胞诱导分化为胰岛分泌细胞治疗1型糖尿病[J].医学分子生物学杂志,2012,9(3):221-225,5.
