医学分子生物学杂志2012，Vol.9Issue(3)：226-230,5.DOI:10.3870/j.issn.1672-8009.2012.03.015
SUMO化修饰在NF-κB信号通路中的作用
Role of SUMO Modification in NF-κB Signaling Pathway
黄炜 1徐勇1
作者信息
- 1. 泸州医学院附属医院内分泌科,四川省泸州市,646000
- 折叠
摘要
Abstract
Sumoylation (SUMO) , similar to ubiquitination , as an important protein post-trans-lational modification, and plays an essential role in cell signal transduction , nucleocytoplasmic transport, and transcriptional regulation. Nuclear factor-KB pathway is recognized as a crucial regulatory pathway involved in inflammation and immune responses . Recent studies have shown that the SUMO is extensively implicated in the regulation of NF-kB signaling pathway through various mechanisms. Importantly , understanding the relationship between SUMO and NF -kB may facilitate prevention and treatment of the related diseases.关键词
小泛素相关修饰物/SUMO化修饰/核因子-κBKey words
SUMO/sumoylation/NF-kB分类
医药卫生引用本文复制引用
黄炜,徐勇..SUMO化修饰在NF-κB信号通路中的作用[J].医学分子生物学杂志,2012,9(3):226-230,5.
