中北大学学报（自然科学版）2012，Vol.33Issue(3)：300-303,4.DOI:10.3969/j.issn.1673-3193.2012.03.015
基于香豆素-茚满二酮共轭物的硫醇比色探针
Cumarin-Indandione Conjugate as a Colorimetric Probe for Thiols
摘要
Abstract
A colorimetric probe for thiols was developed by using a cumarin-indandione conjugate based on the Michael addition of thiol to α,β-unsaiurated double bond. The Michael addition of a thiol group to Michael acceptor of 1 blocked the intramolecular charge transfer (ICT) from the electron-rich diethylaminocoumarin group to the electron-poor Michael acceptor, leading to a blue shift in the absorption spectra with an evident color change from blueviolet to colorless. The probe exhibited higher selectivity toward thiols (Cys, Hey and GSH) than other amino acids. And the detection limit for Cys was 6. 9×10-7mol/L.关键词
香豆素/比色/硫醇/1,3茚满二酮Key words
coumarin/ colorimetric/ thiol/ 1 ,3-indandione分类
化学化工引用本文复制引用
周先树,苗利强,刘滇生..基于香豆素-茚满二酮共轭物的硫醇比色探针[J].中北大学学报（自然科学版）,2012,33(3):300-303,4.基金项目
国家自然科学基金资助项目(20772074) （20772074）
山西省研究生创新项目(20093002) （20093002）
