化工进展2012，Vol.31Issue(9)：2024-2030,7.
高压静电抗溶剂法制备聚乳酸微球
Development of poly （L-lactide） microspheres in high-voltage electrostatic antisolvent process
摘要
Abstract
An antisolvent,absolute ethyl alcohol was used in the high-voltage electrostatic antisolvent process to prepare poly（L-lactide） microspheres.A 24 factorial experiment was designed to investigate and identify the relative significance of the processing parameters on particle size and particle size distribution of the products.The results indicated that the effect of push speed was dominant in the results regarding particle size.After optimization,the resulting poly（L-lactide） microspheres exhibited good spherical shape,smooth surface and narrow particle size distribution.When the concentration and molecular weight of poly（L-lactide） were 3%（w/v） and 50～100 kDa respectively,the resulting microspheres showed good spherical shape.Fourier transform infrared（FTIR） spectroscopy measurement found no significant structural perturbation.X-ray powder diffraction（XRPD） analysis revealed no significant crystal structural changes.关键词
高压静电体系/抗溶剂/聚乳酸/因子试验Key words
high-voltage eletrostatic system/anti-solvent/poly(L-Lactide)/factorial experiment分类
医药卫生引用本文复制引用
陈爱政,杨月梅,王士斌,孙晴晴,刘源岗,党婷婷..高压静电抗溶剂法制备聚乳酸微球[J].化工进展,2012,31(9):2024-2030,7.基金项目
国家自然科学基金 （）
福建省自然科学基金（2010J05027 2011J01223）项目 （）
