化工学报2012，Vol.63Issue(9)：2831-2835,5.DOI:10.3969/j.issn.0438-1157.2012.09.025
青霉素发酵过程的模型仿真与补料优化
Model simulation of fed-batch penicillin fermentation and optimization of substrate feedrate
摘要
Abstract
The mechanical model of fed-batch penicillin fermentation has been well studied for the last decades, but most of them can hardly be implemented to control fermentation process. Due to this problem, this paper uses Birol' s unstructured model, adjusts temperature and pH dynamics of the fermentation and deduces a simplified penicillin unstructured model. To increase production of penicillin, substrate feedrate which is critical in fermentation process is optimized. Because of the nonlinearity and constraints of the mechanical model, sequential quadratic programming (SQP) algorithm is used to the whole process, in which the feedrate trajectory is divided equally into several intervals to enhance optimization efficiency. Optimization results show that the penicillin concentration and yield are increased compared to the normal input.关键词
青霉素发酵/机理模型/仿真/补料优化Key words
penicillin fermentation/ mechanical model/ simulation/ feedrate optimization分类
化学化工引用本文复制引用
贺晓冉,陈宸,金光石,熊智华..青霉素发酵过程的模型仿真与补料优化[J].化工学报,2012,63(9):2831-2835,5.基金项目
国家自然科学基金项目(60874049) （60874049）
轻工过程先进控制教育部重点实验室开放课题(江南大学)项目. （江南大学）
