湖南中医药大学学报2012，Vol.32Issue(8)：55-57,3.DOI:10.3969/j.issn.1674-070X.2012.08.027.055.03
高容量血液滤过对脓毒症患者可溶性髓样细胞触发受体1与血清降钙素原的影响
Effect of high-volume hemofiltration on sTREM-1 and PCT in patients with sepsis
张蕾 1刘宝1
作者信息
- 1. 安徽省立医院重症医学科,安徽合肥230000
- 折叠
摘要
Abstract
Objective To study the level and significance of sTREM-1 and PCT in peripheral blood of patients with sepsis and evaluate the effects of high volume hemofiltration(PHVHF) on them. Methods 74 patients with sepsis in ICU of Anhui provicial hospital were studied from may 2010 to april 2012. Patients were divided into two groups: sepsis group(n=44),severe sepsis group(n=30). The expression of sTREM-1 and PCT of 74 patients on the day 1 and day 5 was detected. The comparision in the expression of sTREM-1 and PCT within groups was made. 40 patients receiving HVHF treatment .The effects of HVHF on the patients were evaluated .Twenty healthy individuals served as controls. Results The expression of sTREM-1 and PCT was the higher in the severe sepsis group than in sepsis group (P<0.05). Compared with control group,our study indicated that high volume hemofiltration could decrease the abnormal expression of sTREM-1 and PCT more efficiency than routine treatment. Conclusion The expression of sTREM-1 and PCT was increased in sepsis patients and the level were correlate with the severity of sepsis,suggesting that they may play an important role in pathogenesis of sepsis. High volume hemofiltration could decrease their expression effectly. HVHF could rebuild inflammation balance so may be used as one treatment of regulating SIRS on sepsis patients.关键词
脓毒症/炎症反应/降钙素原/可溶性髓样细胞触发受体1/高容量血液滤过Key words
sepsis/procalcitonin/pulse/soluble triggering receptor expression on myeloid cellsl/high volume hemofiltration引用本文复制引用
张蕾,刘宝..高容量血液滤过对脓毒症患者可溶性髓样细胞触发受体1与血清降钙素原的影响[J].湖南中医药大学学报,2012,32(8):55-57,3.
