四川大学学报（医学版）2012，Vol.43Issue(5)：683-686,4.
CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义
Expressions and Significances of CD147,OPN and MMP-2 in Oral Squamous Cell Carcinoma
张弛 1满大鹏 2马术明 2曹树文 3李东文2
作者信息
- 1. 四川大学华西口腔医学院 成都610041
- 2. 佳木斯大学附属第二医院口腔科 佳木斯154007
- 3. 大庆油田总医院病理科 大庆163001
- 折叠
摘要
Abstract
Objective To evaluate the expressions and significances of CD147, OPN and MMP-2 in oral squamous cell carcinoma (OSCC). Methods The expressions of CD147,OPN and MMP-2 were detected by immunohistochemical method (SP) in 35 cases of OSCC. The relationships between the expressions of CD147.OPN and MMP-2 and clinic histopathologic parameters of OSCC were analyzed. Results The expression rates of CD147, OPN and MMP-2 in OSCC tissues were 65. 71%, 71. 43% and 68. 57% respectively. The expressions of CD147, OPN and MMP-2 were positively correlated with tumor histopathologic type, clinical stage and lymph node metastasis (P<0. 05), but not correlated with age, gender and the location of tumor (P>0. 05). The positive correlations were found among the expressions of CD147,OPN and MMP-2 (MMP-2 and CD147,r=0. 653;MMP-2 and OPN,r=0. 540;CD147 and OPIN,r=0. 381;P<0. 05). Conclusion The expressions of CD147,OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.关键词
基质金属蛋白酶诱导因子/骨桥蛋白/基质金属蛋白酶-2/口腔鳞状细胞癌Key words
Extracellular matrix metalloproteinase inducer/Osteopontin/Extracellular matrix/metalloproteinase-2/Oral squamous cell carcinoma引用本文复制引用
张弛,满大鹏,马术明,曹树文,李东文..CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义[J].四川大学学报（医学版）,2012,43(5):683-686,4.
