基础医学与临床2012，Vol.32Issue(10)：1167-1170,4.
血清SCCA水平及盆腔淋巴结HPV16/18感染状况与宫颈鳞癌患者预后的关系
The relation of serum squamous cell carcinoma antigen level and pelvic lymph node HPV 16/18 infection with prognosis of cervical squamous cell carcinoma
摘要
Abstract
Objective To explore the relation of preoperative serum SCCA levels, pelvic lymph node HPV 16/18 infection in patients with cervical squamous cell carcinoma and their prognosis. Methods ELISA was performed to detect the SCCA level and real-time fluorescence quantitative PCR was utilized to analyze the positive rate of pelvic lymph node infection with HPV 16/18. The relation of SCCA level, HPV 16/18 positive rate and the three-year survival rate was investigated. Results The SCCA level was closely related with the infection of HPV 16/18 in pelvic lymph node ( P < 0. 05 ). The mean follow-up time for 35 patients with cervical squamous cell carcinoma was 36 m (rang 12~41 months). Four patients died and 3 year survival rate was 85. 0%. The 3 year survival rates for patients with SCCA positive and negative were 100% and 69. 2% respectively and that were 96. 4% and 57. 1% for patients with positive or negative pelvic lymph node infection with HPV 16/18. The 3-year survival rate for patients with negative SCCA and lymph node HPV 16/18 infection were obviously longer than that of positive ones (P <0. 05) . lymph node metastasis, SCCA level and pelvic lymph node HPV 16/18 infection status were associated with prognosis. Conclusions SCCA level and pelvic lymph node HPV 16/18 infection are associated with the prognosis of cervical squamous carcinoma patients and is a potential markers for cervical squamous carcinoma.关键词
宫颈肿瘤/鳞状细胞癌抗原/人乳头瘤病毒/预后Key words
cervical neoplasms/ squamous cell carcinoma antigen/ human papillomavirus/ prognosis分类
医药卫生引用本文复制引用
曾四元,梁美蓉,李隆玉,刘晖,钟美玲,魏晚霞..血清SCCA水平及盆腔淋巴结HPV16/18感染状况与宫颈鳞癌患者预后的关系[J].基础医学与临床,2012,32(10):1167-1170,4.基金项目
江西省卫生厅基金(20081122) （20081122）
