基础医学与临床2012，Vol.32Issue(10)：1198-1201,4.
葡萄籽原花青素减轻小鼠急性化学性肝损伤
Grape seed procyanidin decreases the acute chemical hepatic injury in mice
邹金发 1刘晓光 2齐凤杰 3叶丽平1
作者信息
- 1. 辽宁医学院病理生理学教研室,辽宁锦州121001
- 2. 辽宁省锦州市95905部队卫生队,辽宁锦州121001
- 3. 辽宁医学院病理教研室,辽宁锦州121001
- 折叠
摘要
Abstract
Objective To investigate the protective effect of grape seed procyanidin on chemical hepatic injury in mice. Methods A chemical hepatic injury mice was developed model with alcohol and carbon tetrachloride respectively ; treating the mice with different concentrations of grape seed procyanidin ( GSP) by intragastric administration as the treatment group; then to detect the serum concentration of alanine aminotransferase ( ALT) and aspartate aminotransferase (AST) ; to analyze the content of superoxide dismutase (SOD) and malondialdehyde (MDA) and to observe the pathological change in the hepatic tissue. Results Two types of acute chemical hepatic injury model were obtained successfully and all indexes in the model groups differed from the control group significantly ( P < 0.01). Compared with the model groups, the content of MDA and serum concentration of ALT and AST in the treatment group decreased dose-dependently (P <0. 05) , but SOD increased in a dose-dependent way. Conclusion GSP exerts protective effect on the alcohol or carbon tetrachloride-induced chemical hepatic injury in the mouse.关键词
葡萄籽原花青素/ALT/AST/SOD/MDAKey words
grape seed procyanidin/ ALT/ AST/ SOD/ MDA分类
医药卫生引用本文复制引用
邹金发,刘晓光,齐凤杰,叶丽平..葡萄籽原花青素减轻小鼠急性化学性肝损伤[J].基础医学与临床,2012,32(10):1198-1201,4.
