激光生物学报2012，Vol.21Issue(1)：36-41,6.DOI:10.3969/j.issn.1007-7146.2012.01.008
人参多糖对新甲型H1N1流感病毒灭活疫苗的免疫增强作用
Antibody Responses Induced by Inactivated New Influenza A Virus (H1N1) Vaccine with Ginseng Polysaccharide as an Adjuvant
摘要
Abstract
Addition of an adjuvant to inactivated influenza vaccines can improve the immune responses and save antigen dosage. Some polysaccharides derived from Chinese medicinal herbs have potential adjuvant effect. In this paper, the adjuvant effect of ginseng polysaccharide (GPS) was explored on inactivated new influenza A virus (H1N1) vaccine. Mice were immunized once with the split vaccine adjuvanted with various dosages of GPS. The serum antibody responses in mice after the vaccination were analyzed by ELISA to evaluate the adjuvant effect of GPS. The immune responses were also compared with those induced by vaccine alone or adjuvanted with alum. The result showed that GPS had the same effect as alum on enhancing the specific IgM and IgG antibody levels induced by the vaccine. The optimum dosage of GPS was 800 μg in immunization. GPS may be an adjuvant candidate for inactivated influenza vaccines.关键词
新甲型H1N1流感病毒/灭活疫苗/人参多糖/佐剂/抗体应答Key words
new influenza A virus (H1N1)/ inactivated vaccine/ ginseng polysaccharide/ adjuvant/ antibody response分类
医药卫生引用本文复制引用
梁艳,黄恋,常海艳,陈则,方芳..人参多糖对新甲型H1N1流感病毒灭活疫苗的免疫增强作用[J].激光生物学报,2012,21(1):36-41,6.基金项目
国家自然科学基金(30972623) （30972623）
省教育厅创新平台开放基金(11K040) （11K040）
省科技厅一般项目(2011SK3109) （2011SK3109）
