激光生物学报2012，Vol.21Issue(4)：322-326,5.DOI:10.3969/j.issn.1007-7146.2012.04.007
雌激素受体α在小鼠海马中的表达研究
Investigation on Expression of Estrogen Receptor Alpha in Mouse Hippocampus
摘要
Abstract
The sex hormone estrogen is a hormonal multi-tasker, contributing to roles as diverse as the differentiation and function of the reproductive tract, memory storage, bone growth and nerve system. Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor Era and Erβ. Recent studies involving ER knockout mice and selective ER agonists suggest that ER a playsan important role in hippocampal function. Little is known about whether the expression of Era is related to aging and gender. In this paper, the expression of Era was examined in mice hippocampus between age, sex and OVX difference. The data suggest that the expression of Era is relatedto aging and gender and imply that the expression of Era is regulated by peripheral estrogen. These results provide a reference for further study that Era involves gene expression regulation of hippocampus and clinical therapy of related diseases.关键词
雌激素/雌激素受体α/海马/表达Key words
estrogen/ Era/ hippocampus/ expression分类
生物科学引用本文复制引用
杨利平,吴耀松,刘辉,陈玉龙,刘明俊..雌激素受体α在小鼠海马中的表达研究[J].激光生物学报,2012,21(4):322-326,5.基金项目
国家自然科学基金(81173177) （81173177）
湖南省科技厅科技计划(2009FJ3012) （2009FJ3012）
湖南省教育厅科技课题(09C1062,10C0018) （09C1062,10C0018）
湖南省环境保护厅科研课题([2009] 364) （[2009] 364）
长沙环境保护职业技术学院应用型科研项目(NXJ0807) （NXJ0807）
