河南理工大学学报：自然科学版2012，Vol.31Issue(5)：627-632,6.
具抗肿瘤活性的G-四链体核酸研究进展
Antiproliferative Activity of G-quadruplex Nucleic Acids
摘要
Abstract
G-quadruplexes(G4s) are four-stranded nucleic acid structures adopted by some repetitive guanine-rich sequences.G4 sequences are highly prevalent in human genome and telomere.Recently,some synthetic G4s have been reported to have cancer-selective antiproliferative activity.AS1411,a 26-mer G4 DNA,is currently in phase II clinical trials as an anticancer agent.The structures,functions,antiproliferative activities and mechanisms,and the applications of G4s are reviewed.关键词
G-四链体/核酸/抗癌活性Key words
G-quadruplex/nucleic acid/antiproliferative activity分类
生物科学引用本文复制引用
常天俊,龚红梅,李卫国..具抗肿瘤活性的G-四链体核酸研究进展[J].河南理工大学学报：自然科学版,2012,31(5):627-632,6.基金项目
国家自然科学基金资助项目 （）
