临床肝胆病杂志2012，Vol.28Issue(8)：618-621,4.
70例丙氨酸转氨酶大于15倍正常值上限肝损伤患者的临床分析
Clinical characteristics to identify the etiological diagnosis of hepatic injury in patients with alanine aminotransferase activities over 15 times the upper reference limit
阮建文 1杨京2
作者信息
- 1. 海口市人民医院感染科,海口570208
- 2. 贵阳医学院附属医院,贵阳550004
- 折叠
摘要
Abstract
Objective To investigate distinguishing clinical features that may be useful for etiological diagnosis of hepatic injury, including changes in alanine aminotransferase (ALT) and immunological markers of viral infection. Methods Seventy patients with initial baseline ALT that was greater than 15 times the upper limit of normal (15 × ULN) were recruited to the study between January 2011 and December 2011. Hepatic function markers (bilirubin, ALT, prothrombin time, and alkaline phosphatase) were measured by standard biochemical assays and immunological markers of hepatitis virus [ hepatitis B e antigen ( HBeAg) and hepatitis B surface antigen ( HBsAg) and HEV and HBV DNA ] were examined by immunoassays and quantitative PCR. Changes in ALT over several weeks were statistically analyzed for correlation with laboratory data. Results Among the inpatient study participants, 74. 3% reacted with a single antibody, 5. 7% reacted with two kinds of antibodies, and 20.0% reacted with no antibodies. There was no remarkable difference in laboratory data for these groups. However, ALT decreased in a logarithmic - linear manner in conjunction with the development of illness. In HEV - infected patients, the ALT levels decreased more rapidly. Conclusion Immunological markers of viral infection and changes in ALT can facilitate etiological diagnosis of patients with hepatic injury that present with 15 × ULN of ALT.关键词
丙氨酸转氨酶/肝疾病Key words
alanine transaminase/ live diseases分类
医药卫生引用本文复制引用
阮建文,杨京..70例丙氨酸转氨酶大于15倍正常值上限肝损伤患者的临床分析[J].临床肝胆病杂志,2012,28(8):618-621,4.
