临床肝胆病杂志2012，Vol.28Issue(9)：711-713,720,4.
SnoN的基本特征、生物学功能及其在肝纤维化中的作用
Characteristics, function, and role of SnoN in liver fibrosis
摘要
Abstract
The Smad transcriptional co - repressor ski - related novel protein N ( SnoN) is an important negative regulator of the tumor growth factor -beta 1 (TGFβl )/Smad signaling cascade. The SnoN protein can repress Smad - mediated transactivation of TGFβ target genes in the nucleus and cytoplasm of cells. TGFβl is a well - characterized profibrotic cytokine that is believed to play a crucial role in tissue fibrogenesis in a wide range of organs. Extensive studies have suggested that TGFβl is one of the most important factors mediating the onset and progression of various fibrotic diseases. Recently, SnoN has been shown to reduce liver fibrosis in rat models. In this review, we discuss the recent progress in understanding SnoN characteristics, function, and role in liver fibrosis.关键词
SnoN/肝硬化/转化生长因子B/Smad蛋白质类Key words
SnoN/ liver cirrhosis/ transforming growth factor beta/ smad proteins分类
医药卫生引用本文复制引用
刘瑞霞,齐海宇,王婧,阴赪宏..SnoN的基本特征、生物学功能及其在肝纤维化中的作用[J].临床肝胆病杂志,2012,28(9):711-713,720,4.基金项目
国家自然科学基金(8107313) （8107313）
中国肝炎防治基金会王宝恩肝纤维化研究基金(20090042) （20090042）
