临床神经外科杂志2012，Vol.9Issue(4)：213-216,4.DOI:10.3969/j.issn.1672-7770.2012.04.008
MMP-2及PTEN在人脑星形细胞瘤中的表达及意义
Expression and significance of matrix metalloproteinase-2 and PTEN in human brain astrocytoma
夏大勇 1徐善水 1江晓春 1李真保 1戴易 1毛捷 1包正夫 1方兴根 1朱明峰1
作者信息
- 1. 241000芜湖,皖南医学院弋矶山医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the expressions of MMP-2 and the tumor suppressor genes PTEN in human brain astrocytoma and their relationships between the expressions and tumor invasion. Methods The expressions of MMP-2 and phosphatase and tensin homolog deleted on chromosome ten (PTEN) protein were examined by immunohistochemistry ( SABC method) in 50 human brain astrocytoma tissues and 10 nomal brain tissues,and their relationships of clinicopathological factors of human brain astrocytoma were analyzed. Results The expression rates of MMP-2 and PTEN had significantly difference between low grade human brain astrocytoma tissues and high human brain astrocytoma tissues. In nomal brain tissues (P<0.01),as the tumor's malignancy degree increased, the expression of MMP-2 increased but the expression of PTEN decreased. The expression of MMP-2 was negatively correlation with the expression of PTEN in hunman brain astrocytoma ( Rs =-0.518 , P <0.01). Conclusions MMP-2 and PTEN are potential markers for differentiation and metastasis of human brain astrocytoma. Combined detection of MMP-2 and PTEN can estimate the biological behaviour and pathological grade.关键词
人脑星形细胞瘤/基质金属蛋白酶2/基质金属蛋白酶诱导因子/第10染色体丢失的磷酸酶/免疫组织化学Key words
brain astrocytoma/ MMP-2 /EMMPRIN/ PTEN/ immunohistochemis分类
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夏大勇,徐善水,江晓春,李真保,戴易,毛捷,包正夫,方兴根,朱明峰..MMP-2及PTEN在人脑星形细胞瘤中的表达及意义[J].临床神经外科杂志,2012,9(4):213-216,4.
