临床误诊误治2012，Vol.25Issue(7)：65-68,4.DOI:10.3969/j.issn.1002-3429.2012.07.030
胃黏膜腺体上皮反应性增生与异型增生的判断及临床意义
Diagnosis and Clinical Significance of Gastric Tunica Mucosa Epithelial Reactive Hyperplasia and Dysplasia
胡艳萍 1崔莉 1杨建杰 1刘彤 1王秀芳 1刘凤阁1
作者信息
- 1. 101149北京,首都医科大学潞河教学医院病理科
- 折叠
摘要
Abstract
Objective To explore the clinicopathologic features and the clinical significance of the P53 and proliferating cell nuclear antigen ( Ki-67) expression for gastric epithelial reactive hyperplasia (GERH) and gastric epithelial low grade dysplasia (GELD) . Methods 139 patients with gastric mucosa biopsy combined with epithelial atypical hyperplasia during January 2010 and December 2011 were divided into GERH group (n = 106) and GELD group (n =33) , based on histomorphology characteristics in pathological change of literature standard. The expression of P53 and Ki-67 in two groups were analyzed. Results In GERH group, most of the patients had obvious inflammation history, and reactive hyperplasia showed differentiation gradually to mucosa surface or to inherent membranae without clear boundary. In GELD group there was obviously clear focal distribution without inflammation, and epithelial dysplasia could extend to mucosa surface or to inherent membranae. The positive expression rate of P53 in GERH group and GELD group were 2.83% and 15. 15% respectively, and there was significant difference (P <0. 05). In GERH group, the positive expression rate ( > 10% ) of Ki-67 was 24.53% (26 patients) , and most of the positive cells located at basal part of gastric pits (under 1/3) were in 95 patients (89.62% ). In GELD group, the positive expression rate ( > 10% ) of Ki-67 was 90.90% (30 patients), and the positive cells located at basal and lateral of gastric pits (at 1/3) were in 13 patients (39. 39% ) , The differences were of statistical significance in expressive amount and distributed positions (χ2 =46.10, P <0. 005; χ2= 14. 83, P <0. 005). Conclusion The reactive hyperplasia and low grade dysplasia in gastric epithelial can be differentiated by the clinicopathologic features and expression of P53 and Ki-67.关键词
胃黏膜/活组织检查/反应性增生/异型增生/P53/Ki-67Key words
Gastric mucosa/ Biopsy/ Reactive hyperplasia/ Atypical hyperplasia/ P53/ Ki-67分类
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胡艳萍,崔莉,杨建杰,刘彤,王秀芳,刘凤阁..胃黏膜腺体上皮反应性增生与异型增生的判断及临床意义[J].临床误诊误治,2012,25(7):65-68,4.
