临床误诊误治2012，Vol.25Issue(7)：71-73,3.DOI:10.3969/j.issn.1002-3429.2012.07.032
急性脑梗死患者血清胶质纤维酸性蛋白和S100-β蛋白水平变化
Observation of Glial Fibrillary Acidic Protein and S100-β Protein in Serum of Patients with Acute Cerebral Infarction
陈景红 1李娜 1高俊淑 1王建华 1郭振华 1王天俊1
作者信息
- 1. 050051石家庄,河北省人民医院神经内科
- 折叠
摘要
Abstract
Objective To explore the role of serum glial fibrillary acidic protein and S100-β protein, the relations of infarct volume and scores of neurologic impairment of patients with acute cerebral infarction. Methods We serially (on 3rd ,7th , and 14th day) measured the serum levels of GFAP and S100-β protein by enzyme linked immunosorbent assay (ELISA). We also analyzed the relations of infarct volume with scores of neurologic impairment. Results Expressions of GFAP were significantly increased (on 3rd, 7th, and 14th day) in trerapy group compared with that of control group. Highest expression of GFAP occurred on 7th day, and they remained significantly elevated on 14th day after pathogenesy. Highest expression of S100-β protein occurred on 3rd day, and they were normal on 7th day and 14th day after pathogenesy. Expression of GFAP and expression of S100-β protein were all correlated with infarct volume and scores of neurologic impairment. Conclusion GFAP and S100-β protein may play an important role in the pathophysiology of pristine pathogenesy, physiology and repair process. Serum levels of GFAP and S100-β protein can provide the basis for diagnosis and treatment of ACI.关键词
急性脑梗死/神经胶质原纤维酸性蛋白质/S100蛋白质类Key words
Acute cerebral infarction/ Glial fibrillary acidic protein/ S100 protein分类
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陈景红,李娜,高俊淑,王建华,郭振华,王天俊..急性脑梗死患者血清胶质纤维酸性蛋白和S100-β蛋白水平变化[J].临床误诊误治,2012,25(7):71-73,3.
