南京理工大学学报（自然科学版）2012，Vol.36Issue(4)：706-710,5.
超临界CO2抗溶剂结晶制备枸橼酸颗粒的产率优化
Optimization of Production Rate for Citric Acid Particle Preparation with Supercritical CO2 Antisolvent Crystallization
摘要
Abstract
To further improve the production rate of the citric acid particle preparation with supercritical CO2 anti-solvent crystallization,using the built small-scale apparatus in lab,the effects of the initial concentration of solution, operation temperature, operation pressure and pressure-holding time on the production rate are investigated in sequence. The technology optimization concerning the production rate is performed with the aid of the experimental arrangement of uniform design. The results show that, the production rate increases firstly and decreases later with the increase of the , operation temperature, and increases with the increase of initial concentration of solution, operation pressure or pressure-holding time, but the increasing tendency weakens slowly during the final stage of the operation. Besides, the effect degree order of different factors on the production rate is the initial concentration of solution>operation pressure>operation temperature>pressure-holding time, and under the predetermined investigation scope, the optimum technology combination is the initial concentration of solution at 0. 35 g/mL,the operational temperature at 33 t ,the pressure at 12. 5 MPa and the pressure-holding time at 3, 5 h, while the corresponding production rate can be over 80%.关键词
超临界CO2/抗溶剂结晶/枸橼酸/颗粒制备/产率优化Key words
supercritical CO2/ antisolvent crystallization/ citric acid/ particle preparation/ optimization of production rate分类
化学化工引用本文复制引用
黄德春,刘巍,乐龙,戴琳,史益强..超临界CO2抗溶剂结晶制备枸橼酸颗粒的产率优化[J].南京理工大学学报（自然科学版）,2012,36(4):706-710,5.基金项目
中央高校基本科研业务费专项资金(JKQ2011022) （JKQ2011022）
江苏省自然科学基金(BK2012763) （BK2012763）
