南京师大学报（自然科学版）2012，Vol.35Issue(2)：93-96,4.
气相色谱法测定磺胺多辛中的冰醋酸和N,N-二甲基甲酰胺残留
Determination of Residual Acetic Acid and N, N-Dimethylformamide in Sulfadoxine by Capillary Gas Chromatography
井玥 1王刚 1张爱莲 1盛晓玲 1龚祝南1
作者信息
- 1. 南京师范大学生命科学学院,江苏南京210046
- 折叠
摘要
Abstract
Objective: To establish a method for the determination of residual organic solvent, acetic acid and NN-Dime-thylformamide(DMF) in sulfadoxine. Method; Capillary gas chromatographic method was introduced for the determination, residual organic solvent was extracted from sulfadoxine with methanol and separated in DB-WAX capillary column with FID detector. Result: the linear relation of acetic acid and NN-Dimethylformamide was Y = 3. 565 IX + 4. 078 4 ( r = 0. 999 3) and Y = 7. 248 9X - 7. 488 9 ( r = 0. 999 6 ), with accuracy RSD ( 1. 8% and 3. 3% ) , recovery rate (99. 7% and 100. 1% ) , LOD (35. 46 ng/mL and 66. 5 ng/mL) respectively. Conclusion; The method was accurate, reliable and high sensitivity for determination of residual organic solvent in sulfadoxine.关键词
磺胺多辛/冰醋酸/N/N-二甲基甲酰胺/毛细管气相色谱/残留Key words
sulfadoxine/ acetic acid/ N/ N-Dimethylformamide/ capillary gas chromatography/ residue分类
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井玥,王刚,张爱莲,盛晓玲,龚祝南..气相色谱法测定磺胺多辛中的冰醋酸和N,N-二甲基甲酰胺残留[J].南京师大学报（自然科学版）,2012,35(2):93-96,4.
