南京医科大学学报（自然科学版）2012，Vol.32Issue(9)：1215-1218,4.
右旋糖酐40缓解犬体外循环实验模型中的炎症反应
Dextran-40 reducing the inflammation during cardiopulmonary bypass of the mongrel dog
摘要
Abstract
Objective:To establish the extracorporeal circulation model of the mongrel dog and to investigate the effect of dextran- 40 on inflammation and atrial fibrillation after extracorporeal circulation. Methods: Twelve male mongrel dogs underwent cardiac bypass. Two groups were formed. In experimental group (re = 6),dextran-40 infusion was administered at a dose of 7.5 ml/kg before the initiation of cardiopulmonary bypass and at a dose of 12.5 ml/kg after the cessation of cardiopulmonary bypass. Identical amounts of saline was administered in control group (re = 6). Blood samples were taken from the coronary artery and coronary sinus before bypass,20 min after beginning of bypass,and 4 h,24 h,and 48 h after termination of bypass and initiation of reperfusion. Plasma interleukin (IL)-6,IL-8,IL-10,tumor necrosis factor (TNF)-α,C reactive protein (CRP) ,troponin I (Tnl) were measured in these samples. And heart rate,mean blood pressure,ejection fraction(EF) and cardiac index (CI) were measured at the same time point. Pacing-induced atrial fibrillation was compared between two groups. The t test,x2 test and ANOVA were used for statistical analysis. Results:In experimental group,lower peak plasma levels of IL-6,IL-8,IL-10,TNF-a,CRP and Tnl were found. There was no significant difference in heart rate and mean blood pressure between two groups. Higher figures of the cardiac index and ejection fraction were noted in experimental group. Conclusion: Dextran-40 reduces the systemic inflammatory response, cardiac troponin I release,protects cardiac function and may relieve atrial fibrillation following cardiopulmonary bypass.关键词
右旋糖酐/炎症反应/心房纤颤/体外循环Key words
dextran/inflammation/atrial fibrillation/cardiopulmonary bypass分类
医药卫生引用本文复制引用
刘培生,陈鑫,庄瑜..右旋糖酐40缓解犬体外循环实验模型中的炎症反应[J].南京医科大学学报（自然科学版）,2012,32(9):1215-1218,4.基金项目
南京市医学科技发展青年科技人才启动项目(QYK10136) （QYK10136）
