南京医科大学学报（自然科学版）2012，Vol.32Issue(9)：1241-1245,5.
血管内皮细胞生长因子和血浆组织激肽释放酶与冠状动脉狭窄的相关性研究
Correlation between vascular endothelial growth factor,plasma tissue kallikrein and coronary artery stenosis
摘要
Abstract
Objective:To determine the association of plasma vascular endothelial growth factor(VEGF) and tissue kallikrein (TK) levels with coronary artery stenosis degree in coronary artery disease patients. Methods:According to coronary angiography, the patients were stratified as 50% to 69% stenosis in one artery (group 1 ,n = 32) ,70% to 99% stenosis in one artery and (or) 50% to 99% stenosis in two or three artery (group 2,n = 29),total occlusion in one and(or) multi-artery (group 3,n = 25) and no stenosis (control,n = 24). Plasma TK and VEGF concentrations were measured by ELISA. Results:TK augmented from (781 ± 63) pg/ml in no stenosis to (1900 ± 461) pg/ml in group 1, (2203 ± 268) pg/ml in group 2 and (4 823 ± 1005) pg/ml in group 3. VEGF level was (54.75 ± 23.22) pg/ml in no stenosis, (54.29 ± 23.22) pg/ml in group 1 ,(63.00 ± 26.72) pg/ml in group 2 and (71.27 ± 17.86) pg/ml in group 3. Linear multivariate stepwise analysis showed that TK level was independently associated with coronary artery stenosis degree(P < 0.001) after adjusting for hypertension(P = 0.990),diabetes mellitus(P = 0.574) and smoking(P = 0.561). No association was found between VEGF level and obstruction grading. A threshold of 1 725 pg/ml provided the maximized predictive value of total obstruction. Conclusion:Plasma TK level was significantly higher in the presence of coronary artery disease. TK level was independently associated with coronary artery stenosis grading. TK measurement may be useful for the diagnosis of coronary artery stenosis grading.关键词
组织激肽释放酶/血管内皮细胞生长因子/血管新生/冠状动脉/粥样硬化Key words
tissue kallikrein/vascular endothelial growth factor/angiogenesis/coronary artery/atherosclerosis分类
医药卫生引用本文复制引用
傅聪,罗丹,朱建,李拥军,鞠成伟,陆静,章晓国,姚玉宇,马根山,冯毅,汤成春,陈忠,戴启明,童嘉毅,丁建东..血管内皮细胞生长因子和血浆组织激肽释放酶与冠状动脉狭窄的相关性研究[J].南京医科大学学报（自然科学版）,2012,32(9):1241-1245,5.基金项目
国家自然科学基金资助(30871071,81070085) （30871071,81070085）
