青岛大学医学院学报2012，Vol.48Issue(5)：390-392,3.
6-羟基多巴胺对星形胶质细胞hepcidin表达的影响
EFFECTS OF 6-HYDROXYDOPAMINE ON hepcidin mRNA EXPRESSION IN ASTROCYTES
摘要
Abstract
Objective To investigate the expression of hepcidin mRNA in astrocytes treated by 6-hydroxydopamine (6-OHDA). Methods By employing real time PCR, the expression of hepcidin mRNA in primarily cultured astrocytes treated by 6-OHDA for six or 24 hours was detected, and the cells cultured with serum-free medium were served as controls. Results Compared with the controls, the expressions of hepcidin mRNA levels in 6 h and 24 h-6-OHDA-treated astrocytes mRNA were down-regulated, the differences being significant (F = 6. 116;q = 4. 314, 4. 467)P<0. 05) ; but the difference between that of 6 h and 24 h-treatment was not (q = 0. 017,P>0. 05). Conclusion Under the state of oxidative stress, hepcidin in astrocytes might involve in intracellular iron metabolism disorders.关键词
hepcidin/6-羟基多巴胺/星形胶质细胞Key words
hepcidin/ 6-hydroxydopamine/ astrocytes分类
生物科学引用本文复制引用
宋捷,宋宁,姜宏..6-羟基多巴胺对星形胶质细胞hepcidin表达的影响[J].青岛大学医学院学报,2012,48(5):390-392,3.基金项目
国家自然科学基金(30900477),山东省中青年科学家奖励基金(BS2010SW005),教育部博士点基金(20093706120002) （30900477）
