四川大学学报（自然科学版）2012，Vol.49Issue(4)：871-878,8.DOI:10.3969/j.issn.0490-6756.2012.04.029
新型酰胺类化合物的合成及抗植物病原真菌活性研究
Synthesis and screening for potential against phytopathogenic fungi activity of novel amides
摘要
Abstract
In order to search for novel agrochemicals with potential anti-phythopathogenic fungi activity, a series of daphneone analogues were designed and synthesized. They were screened for antifungal activities against five phytopathogenic fungi; Rhizoctonia solani, Botrytis cirerea , Gibberella zeae , Bipolaris maydis, and Sclerotia sclerotium. The preliminary bioassays indicated that some compounds exhibited a fairly good activity. N-(2-fluorophenyl)-2, 4, 5-trimethyl-3-furancarboxamide (p) showed a strong fungistatic activity against R. solani (98% and 99% growth inhibition at 20 and 200 mg/L, respectively). Two compounds, N-(4-fluorophenyl)-2, 5-dimethyl-3-furancarboxamide (h) and N-(2-fluorophenyl)-2, 5-dimethyl-3-furancarboxamide (k) at 200 mg/L inhibited the growth of Sclerotia sclerotium at 94% and 90% , respectively. The EC50 values for compound k were 0. 034 mg/L, while for the control fungicide carbendazim were 0. 050 mg/L. According to the EC50 and the preventive activity of compound k, it can be inferred that compound k had a very good activity against Rhizoctonia solani. Thus, the compound k -was demonstrated to be the most promising candidate for further study.关键词
瑞香狼毒/抗真菌活性/合成Key words
Stellera chamaejasme L. / antifungal activity/ synthesis分类
化学化工引用本文复制引用
周国萍,刘伟,金洪,陶科,侯太平..新型酰胺类化合物的合成及抗植物病原真菌活性研究[J].四川大学学报（自然科学版）,2012,49(4):871-878,8.基金项目
国家自然科学基金(20572076) （20572076）
国家"十一五"科技支撑计划(2006BAE01A01-14) （2006BAE01A01-14）
