四川医学2012，Vol.33Issue(9)：1527-1529,3.
槲皮素对香烟暴露大鼠血清炎症因子和氧化应激水平的影响
The effect of quercetin on serum inflammatory cytokines and oxidative stress in cigarette smoke-exposed rats
万春 1申永春 1陈珍妮 2杨婷 1汪涛 1陈磊 1文富强1
作者信息
- 1. 四川大学华西医院呼吸内科,四川成都610041
- 2. 四川大学华西公共卫生学院,四川成都610041
- 折叠
摘要
Abstract
Objective To evualate the effect of quercetin on inflammatory cytokines and oxidative stress in serum of cigarette smoke-exposed rats. Methods 20 SD rats were randomly divided into 4 groups; normal control group (group A) , quercetin control group (group B) , cigarette smoke - exposed group (group C) , cigarette smoke + quercetin group (group D). Rats in group C and D revieved cigarette smoke exposure for 4 weeks and rats in group D were also treated with quercetin intraperitionally, Rats in group A were injected with saline and rats in group B were only treated with quercetin. 4 weeks later, rats were sacrificed and TNF-α, IL-8, superoxide dismutase (SOD) activity, malondialdehyde (MDA) and total antioxidant capacity (T-AOC) in the serum of rats were examined. Results Cigarette smoke for 4 weeks increased the expression of TNF-a and IL-8, decreased SOD activity and T-AOC level and increased MDA level in the serum of rats, quercetin intervention improved such changes. Conclusion quercetin may decrease cigarette smoke-induced high inflmmatory cytokines expression and oxidative stress level in the serum of rats.关键词
槲皮素/香烟/炎症因子/氧化应激Key words
quercetin/ cigarette smoke/ inflammatory cytokine/ oxidative stress分类
医药卫生引用本文复制引用
万春,申永春,陈珍妮,杨婷,汪涛,陈磊,文富强..槲皮素对香烟暴露大鼠血清炎症因子和氧化应激水平的影响[J].四川医学,2012,33(9):1527-1529,3.
