四川医学2012，Vol.33Issue(9)：1549-1551,3.
高血压病患者瘦素与胰岛素抵抗及炎症的相关性研究
Study on the relationship of serum leptin level with insulin resistance and inflammation in primary hypertensive patients
摘要
Abstract
Objective To study the relationship of serum leptin level with insulin resistance and inflammation in Primary Hypertensive patients. Methods The basic information was collected in 50 hypertensive patients without diabetic history and 40 normal control. Blood pressure, waist circumference .height and body weight were measured. Then blood samples were taken from them for measurement of biochemical indicators. Fasting Serum Leptin was tested by enzyme linked immunosorbent assay (EL1SA). Insulin resistance index(IRI) was applied to estimate insulin resistance. Results The levels of waist circumference, IRI, hsCRP and Serum leptin were significantly higher in the hypertensive patients than those in control group (P ＜0. 05). Pearson relation analysis showed that the leptin level of the hypertensive patients was positively correlated with waist circumference, IRI and hsCRP(P＜0. 05). In normal control group,the leptin level was positively correlated with IRI and hsCRP(P ＜0. 05). Conclusion The results suggest that hyperleptinemia or leptin resistance was found in hypertensive patients. Furthermore, hyperleptinemia or leptin resistance is significantly correlated with systemic inflammation and insulin resistance.关键词
高血压/瘦素/胰岛素抵抗/炎症Key words
hypertension /leptin/ insulin resistance inflammation分类
医药卫生引用本文复制引用
彭清,王小洁,余琴,杨悠,陈梅..高血压病患者瘦素与胰岛素抵抗及炎症的相关性研究[J].四川医学,2012,33(9):1549-1551,3.基金项目
泸州医学院学院课题资助(编号:200932) （编号:200932）
