肿瘤预防与治疗2012，Vol.25Issue(5)：284-287,4.DOI:10.3969/j.issn.1674-0904.2012.05.003
P53、MDM2在鼻咽癌组织中的表达及其与鼻咽癌生物学行为、预后关系的分析研究
Expression of p53 and MDM2 in Nasopharyngeal Carcinoma and their Correlation with the Biological Behavior and Prognosis of Nasopharyngeal Carcinoma
摘要
Abstract
Objective; To determine the expression of p53 and MDM2 in nasopharyngeal carcinoma and to investigate the relationship between them and biological behavior , survival rate of nasopharyngeal carcinoma. Methods: Clinical data of 96 nasopharyngeal carcinoma patients accepted radical radiotherapy and chemotherapy in our hospital from 2005 - 2009 were retrospective analyzed. All patients were diagnosed by biopsy of the nasopharynx before treatment. Patients accepted the 6-MV X-ray intensity-modulated radiotherapy combined with cisplatin-based chemotherapy regimen and were followed up for more than 3 years. The expression levels of P53, MDM2 protein in 96 cases of nasopharyngeal specimens were detected by immunohistochemical SP method and their relationship with the clinical parameters, prognosis were analyzed. Results; The positive expression rate of P53 and MDM2 was 65. 6% (63/96) , 79. 17% (76/96) respectively. The positive expression rate of P53 was correlated with different T-stage(P = 0. 000) . Expression of MDM2 in different N stage in nasopharyngeal carcinoma had statistical difference(P = 0. 001) . The positive expression of P53 indifferent clinical stages was statistically different (P = 0.037). The expression of P53 and MDM2 was negatively correlated(r = -3. 24,P ＜0. 05) . 3-year Disease-free survival(DFS)and overall survival (OS) of on the patients were 73.9% , 84.4% respectively. Conclusion; The expression of P53 and MDM2 are related with the biological behavior of nasopharyngeal cancer. The expression of P53 and MDM2 are nega- tively correlated. P53 can be used as a prognostic factor for overall survival.关键词
P53/MDM2/免疫组织化学法/鼻咽癌Key words
P53/ MDM2/ Immunohistochemical SP Method /Nasopharyngeal Carcinoma分类
医药卫生引用本文复制引用
张鹏,吴松珂,徐鹏,冯梅,范子煊,李厨荣,付彬玉,王卫东,郎锦义..P53、MDM2在鼻咽癌组织中的表达及其与鼻咽癌生物学行为、预后关系的分析研究[J].肿瘤预防与治疗,2012,25(5):284-287,4.基金项目
本研究由四川省科技厅应用基础计划(项目编号:2011JY0109)资助 （项目编号:2011JY0109）
