山东农业科学2012，Vol.44Issue(8)：111-115,5.
生物监测法测定氟啶虫酰胺的人体暴露水平
Detection of Exposure Level of Flonicamid for Orchard Farmers by Biological Monitoring Method
于爱丽 1朱永哲 1Kim Jeong-han2
作者信息
- 1. 青岛农业大学化学与药学院,山东青岛266109
- 2. 首尔大学农业与生物技术学院,韩国首尔151742
- 折叠
摘要
Abstract
To get the actual exposure level of flonicamid for human body, the concentration of flonicamid and its metabolites in the urine of operators after spraying were detected and analyzed. The LOD of flonicamid was 0.005 mg/L by LC - MS/MS, and the standard curve coefficient R2 was 0.9993. The LOD of flonicamid metabolites TFNG and TFNA were both 0.0025 mg/L and the standard curve coefficients R were 0. 9995 and 0.9997, respectively. The recovery rate of flonicamid, TFNG and TFNA extracted by ethyl acetate were 72. 3% , 78. 2% and 80% respectively, indicating the extraction and analysis method was valid. The urine of two operators who sprayed 2 000 times solution of 10% flonicamid WG for 4 hours under the protection of garment and gloves was collected after 12, 24 and 36 hours for biological monitoring. The exposure level of the two operators were below 0. 039 and 0, 066μg/μg BW per day respectively, which were only 0. 16% and 0.27% of the NOEL of flonicamid (25 μg/μg BW per day) , indicating the exposure level was within the acceptable range.关键词
氟啶虫酰胺/人体暴露水平/生物监测Key words
Flonicamid/ Exposure level for human body/ Biological monitoring分类
化学化工引用本文复制引用
于爱丽,朱永哲,Kim Jeong-han..生物监测法测定氟啶虫酰胺的人体暴露水平[J].山东农业科学,2012,44(8):111-115,5.
