山东医药2012，Vol.52Issue(30)：1-3,3.
颅咽管瘤组织中IFN-α、IFN-αR、OPN的表达变化及意义
Expression and significance of IFN-α, IFN-αR, OPN in craniopharyngioma
摘要
Abstract
Objective To observe expression of IFN-α, IFN-αR, OPN in craniopharyngima and investigate its significance. Methods Surgical specimens from 58 patients with craniopharyngioma( craniopharyngioma group) and 12 patients underwent cerebral cortex colostomy(control group) were retrieved. After surgical resection, specimens were fixed in 10% neutral buffered formalin and embedded in paraffin blocks. Sections (4-u,m thick) were stained with haematoxylin-eosin for histological examination. IFN-α, IFN-αR, OPN in surgical specimens were detected by immunohistochemical staining. Results In the craniopharyngioma tissues, inflammatory cell infiltration were evident, but not in the normal brain tissues. It was found that the expression level of IFN-α, IFN-αR, OPN of craniopharyngioma tissues were significantly higher than that in normal brain tissues (all P <0. 05). Expression of IFN-α, IFN-αR, OPN in craniopharyngioma group were higher than control group, which in ameloblastic cell type were higher than the squamous papillary type, and recurrence craniopharyngioma tissue were higher than gnset craniopharyngioma ( all P < 0.05). Expression of IFN-a and OPN were positively correlated in craniopharyngioma organization(rs = 0.814, P<0.0l ). Conclusions IFN-α, IFN-aR, OPN are over-expressed in the craniopharyngiomas. They are well-established risk factors of craniopharyngioma and play an important role in the craniopharyngioma inflammation.关键词
颅咽管瘤/α-干扰素/骨桥蛋白/炎症/细胞因子Key words
craniopharyngioma/ interferon-α/ osteopontin/ inflammatory factors分类
医药卫生引用本文复制引用
黄广龙,吴欣洪,郭邦明,漆松涛..颅咽管瘤组织中IFN-α、IFN-αR、OPN的表达变化及意义[J].山东医药,2012,52(30):1-3,3.基金项目
国家自然科学基金资助项目(81072067) （81072067）
南方医院院长基金资助项目(2010C004). （2010C004）
