山东医药2012，Vol.52Issue(33)：25-27,3.
嗅鞘细胞联合血管内皮生长因子促进周围神经再生的实验研究
Olfactory ensheathing cell and vascular endothelial growth factor promote the sciatic nerve regeneration
王磊 1吕刚 1李永明 1庄培元 1李帅 1贾志强1
作者信息
摘要
Abstract
Objective To study the olfactory ensheathing cell (OECs) and vascular endothelial growth factor ( VEGF) jointed transplant promote the synergy of sciatic nerve regeneration. Methods A total of 60 SD rats were randomly divided into four groups, namely CON group, VEGF or OECs group, and VEGF + OECs group. Making big rat sciatic nerve defect models, respectively infusing right amount physiological saline, VEGF, OECs, VEGF and OECs in renewable indoor. General state of each rat was observed after operation, and at the 4 weeks and 12 weeks, Optical nerve regeneration was observed under electron microscope, detecting rat sciatic nerve electric physiology. Results In VEGF, OECs, VEGF + OECs group, there were statistically significant in data about promoting the growth of rat sciatic nerve fibers role (all P<0.05). Medulated nerve fibre number percross of sclatie nerve and its diameter, electrophysiologic study results and gastrocnemius green weight in VEGF + OECs group were higher than those in CON group. Conclusions VEGF and OECs all can promote the sciatic nerve regeneration, and have synergistic effect.关键词
神经再生/嗅鞘细胞/血管内皮生长因子/移植Key words
nerve regeneration/ Olfactory ensheathing cell/ vascular endothelial growth factor/ transplantation分类
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王磊,吕刚,李永明,庄培元,李帅,贾志强..嗅鞘细胞联合血管内皮生长因子促进周围神经再生的实验研究[J].山东医药,2012,52(33):25-27,3.
