山东医药2012，Vol.52Issue(35)：44-46,3.
宫颈癌组织中Survivin、uPA的表达及意义
Expression and significance of Survivin and uPA in cervical carcinoma tissue
摘要
Abstract
Objective To investigate the roles of Survivin and uPA in the occurrence and development of cervical carcinoma. Methods The expression of Survivin and urokinase plasminogen activator ( uPA) in 47 cases of cervical carcinoma (carcinoma group) , 35 cases of cervical intraepithelial neoplasia (CIN, neoplasia group) and 21 cases of normal endo-metrial tissue (normal group) were detected by immunohistochemistry S-P. The correlation between the two indexes and clinicopathologic parameters of cervical carcinoma. Results The positive expression rates of the Survivin and uPA in carcinoma group and neoplasia group were significantly higher than those in normal group, especially which in the carcinoma group (all P<0.05). Both of their expression were related with lymph nodemetastasis, clinical stage and pathological staging. In cervical carcinoma, the expressions of Survivin and uPA were positively correlated with each other. Conclusion Survivin and uPA play important roles in the occurrence and development of the cervical carcinoma.关键词
子宫内膜肿瘤/Survivin蛋白/尿激酶型纤溶酶原激活剂蛋白/免疫组织化学Key words
cervical carcinoma/ Survivin protein/ urokinase plasminogen activator protein/ immunohistochemistry分类
医药卫生引用本文复制引用
孙峰瑞,孙冬霞,时志民,王蕾,范建..宫颈癌组织中Survivin、uPA的表达及意义[J].山东医药,2012,52(35):44-46,3.基金项目
邯郸市科学技术研究与发展计划资助项目(1023108103-2). （1023108103-2）
