山东医药2012，Vol.52Issue(35)：53-54,2.
Ki67、Survivin蛋白在原发性肝细胞癌组织中的表达及临床意义
Expression and clinical significance of Ki67, Survivin protein in hepatocellular carcinoma tissue
摘要
Abstract
Objective To investigate the role of nuclear proliferation antigen ( Ki67 ) and inhibitor of apoptosis protein Survivin in the occurrence and development of hepatocellular carcinoma ( HCC ) . Methods The expression of Survivin and Ki-67 was examined and compared by S-P immunohistochemistry in normal liver tissue of 20 cases (normal group) and HCC tissue specimens of 50 cases (tumor group) , the relationship between Ki67 and Survivin expression and the clinical pathology features of the HCC patients were analyzed. Results The positive rates of Ki67 and Survivin expression in tumor group were both significantly higher than those in normol group ( both P <0. 01) . The Ki67 and Survivin expression in HCC were both correlated with the envelope invasion, progression of tumor thrombus and metastasis; There expression of Ki67 and Survivinwas was positively correlated with each other. Conclusion Co-detection of Survivin and Ki67 can supply certain evidence on diagnosis and treatment of HCC.关键词
肝细胞癌/细胞核增殖抗原/凋亡抑制蛋白/免疫组织化学Key words
hepaticcellular cancer/ Ki67/ Survivin/ immunohistochemistry分类
医药卫生引用本文复制引用
刘起胜..Ki67、Survivin蛋白在原发性肝细胞癌组织中的表达及临床意义[J].山东医药,2012,52(35):53-54,2.基金项目
湖南省教育厅科学研究资助项目(11C0974). （11C0974）
