生命科学研究2012，Vol.16Issue(4)：357-361,5.
弥漫性大B细胞淋巴瘤发病分子遗传机制的研究进展
Progresses on Molecular Pathogenesis of Diffuse Large B-cell Lymphoma
摘要
Abstract
Diffuse large B-cell lymphoma is the most commonplace type of non-hodgkin's lymphoma in malignant lymphoma according to the Revised European-American Lymphoma (REAL) and World Health Organization (WHO) classification. Diffuse distribution is the pathological feature of malignant large-B lymphoma in-cluding many morphological variants and subtypes. Diffuse large B-cell lymphoma is a genetically and clinically heterogeneous disease. The molecular pathogenesis of DLBCL is very complex involving recurrent translocation of chromosomal 3q27 of bcl-6 and t(14; 18) (q32; q21) of bcl-2, abnormal somatic aberration of Proto-oncogene pim-1, c-myc, RhoH/TTF, and PAX5, genetic deletion and point mutation of P-53, the epige-netic silence of pl6 and the over amplification of Proto-oncogene rel, myc, bcl-2. The function of each gene lesion in DLBCL are reviewed.关键词
易位/异常体细胞高频突变/基因缺失/基因突变/基因扩增/多态性Key words
chromosomal translocation/ abnormal somatic aberration/ gene deletion/ gene mutation/ gene amplification/ polymorphisms分类
生物科学引用本文复制引用
崔蕴博,方琳,刘静..弥漫性大B细胞淋巴瘤发病分子遗传机制的研究进展[J].生命科学研究,2012,16(4):357-361,5.基金项目
教育部新世纪优秀人才计划项目(NCET-11-0518) （NCET-11-0518）
国家自然科学基金资助项目(30971517) （30971517）
中央高校基本科研业务费资助项目(2011JQ015) （2011JQ015）
中南大学研究生创新课题项目(2011ssxt133) （2011ssxt133）
