生物信息学2012，Vol.10Issue(3)：211-216,6.DOI:10.3969/j.issn.1672-5565.2012.03.14
基于一致序列多样性分析的启动子预测方法
Algorithm for Promoter Prediction Based on Analysis of Consensus Sequences Variation
摘要
Abstract
Based on the following features of promoters: (1) Promoter regions include some consistent sequences ,however,consistent sequence has diversity because of nucleotide variation for different promoters; ( 2 ) Positions of consistent sequence are not fixed,instead,their positions are actually more likely to fluctuate in an approximate region; (3) Most of the eukaryotic promoters are related with CpG island. A new method is presented for promoter prediction which adopts a new statistical modeling,and it is the first time to present a new concept " Interval Position Weight Matrix" probability model. Experimental results on large sequences show that the new promoter prediction system is efficient with higher sensitivity and specificity.关键词
启动子预测/真核生物/CpG岛/区间位置权重矩阵Key words
promoter prediction/eukaryotic biology/CpG island/Interval Position Weight Matrix分类
信息技术与安全科学引用本文复制引用
张文燕,武栓虎,王敏强..基于一致序列多样性分析的启动子预测方法[J].生物信息学,2012,10(3):211-216,6.基金项目
国家自然科学基金(61070118). （61070118）
