护理研究2012，Vol.26Issue(25)：2355-2357,3.DOI:10.3969/j.issn.1009-6493.2012.25.022
粒-巨噬细胞集落刺激因子治疗血液肿瘤化疗所致口腔黏膜炎的疗效观察
Observation on curative effect of Granulocyte-macrophage colony-stimulating factor for treatment of chemotherapy induced oral mucositis in hematological tumor patients
摘要
Abstract
Objective: To study the curative effect of granulocyte - macrophage colony--stimulating factor (GM - CSF) suspension for treatment of chemotherapy induced oral mucositis (OM) in hematological tumor patients. Methods:A total of 136 cases of hematological tumor patients with oral mucositis after chemotherapy were selected and randomly divided into observation group and control group, control group cases used the tini-dazole mouthwash for gargling,and the observation group patients used the (GM-CSF) suspension coating the oral ulcer,then to compare the healing of different location and extent of OM patients between both groups. Results: There was statistical significant difference in OM healing time between both groups (P<C0. 01) ; OM healing in lip was the earliest, and OM healing in palate was the latest. Conclusion: For chemotherapy induced OM in hematological tumor patients, the curative effect of (GM - CSF) suspension coating the oral ulcer is better than that of routine tinidazole mouthwash for gargling.关键词
血液肿瘤/化疗/粒-巨噬细胞集落刺激因子/口腔黏膜炎/疗效Key words
hematological tumor/ chemotherapy/ granulocyte - macrophage colony - stimulating factor (GM-CSF)/ oral mucositis (OM)/ curative effect分类
医药卫生引用本文复制引用
敬雪明,梅小平,李芸,罗万红,敬剑英..粒-巨噬细胞集落刺激因子治疗血液肿瘤化疗所致口腔黏膜炎的疗效观察[J].护理研究,2012,26(25):2355-2357,3.基金项目
为四川省卫生厅2011年科研课题,编号:川卫办[2011]717-110321. （）
