陕西师范大学学报：自然科学版2012，Vol.40Issue(5)：72-75,4.
单次可卡因注射对大鼠中脑腹侧被盖区多巴胺能神经元细胞兴奋性的影响
The influence of single cocaine exposure on intrinsic excitability of dopaminergic neurons in ventral tegmental area
摘要
Abstract
Activation of dopaminergic neurons in ventral tegmental area plays an important role in drug addiction.This experiment used whole-cell patch-clamping in midbrain slices,bathing with antagonist PTX,AP—5,CNQX,giving dopaminergic neurons a series of step current,to explore the intrinsic plasticity in VTA dopaminergic neurons after cocaine exposure.The results showed that rheobase decreased and action potentials frequency increased in neurons from cocaine-treated animals.The results indicated that single cocaine exposure increases the intrinsic excitability in ventral tegmental area dopaminergic neurons.关键词
中脑边缘多巴胺系统/可卡因/神经元兴奋性Key words
mesolimibic dopamine system/cocaine/intrinsic excitability分类
生物科学引用本文复制引用
卢敦国,刘一辉,任维..单次可卡因注射对大鼠中脑腹侧被盖区多巴胺能神经元细胞兴奋性的影响[J].陕西师范大学学报：自然科学版,2012,40(5):72-75,4.基金项目
国家自然科学基金资助项目 （）
