实用医学杂志2012，Vol.28Issue(13)：2203-2205,3.DOI:10.3969/j.issn.1006-5725.2012.13.039
肾损伤分子-1在心脏体外循环术后急性肾损伤早期诊断中的应用
Value of urine kidney injury molecule-1 in the early diagnosis of acute kidney injury after cardiopulmonary bypass
陈彩妹 1王凉 1李明秋 1刘斌 1祁真 1刘晓斌 1华佳 1孙铸兴1
作者信息
- 1. 214023,江苏省无锡市,南京医科大学附属无锡人民医院肾内科
- 折叠
摘要
Abstract
Objective To evaluate the value of urine kidney injury molecule-1 (Kim-1) in the early diagnosis of acute kidney injury (AKI) after cardiopulmonary bypass (CPB). Methods Data from 84 patients underwent CPB at Wuxi people's Hospital from May to November 2010 were prospectively investigated. The urine levels of Kim-1 and serum levels of creatinine at different time points were measured. All the patients were divided into AKI group and non-AKI group according to the diagnostic standard of AKI. Results The serum level of creatinine reached peak at 12 ~ 48 h in AKI group, and the urine levels of Kim-1 were increased at 2 h after CPB and later, which was significantly higher than those in non-AKI group at 6 h after CPB and later. After corrected by urine creatintine (Ucr), the ratios of Kim-1/Ucr at corresponding time points were still significantly different between the two groups. For the cutoff value of 300 ng/L of urine level of Kim-1 at 2 h after CPB, the sensitivity was 0.786 and the specificity was 0.821, while for that of 2.0 ng/mg of the ratio of Kim-1/Ucr, those were 0.907 and 0.857 respectively. Conclusion The level of Kim-1 and ratio of Kim-1/Ucr in urine at 2 h after CPB could be used as the early diagnostic predictors of AKI.关键词
体外循环/急性肾损伤/肾损伤分子/心脏手术Key words
Extracorporeal circulation/ Acute kidney injury/ Kidney injury molecule-1/ Cardie surgery procedures引用本文复制引用
陈彩妹,王凉,李明秋,刘斌,祁真,刘晓斌,华佳,孙铸兴..肾损伤分子-1在心脏体外循环术后急性肾损伤早期诊断中的应用[J].实用医学杂志,2012,28(13):2203-2205,3.
