实用肿瘤杂志2012，Vol.27Issue(5)：496-498,3.
恩度加化疗联合局部热疗治疗恶性腹腔积液临床观察
Clinical observation on effect of intraperitoneal Endostar combined with chemotherapy and local hyperthermia on malignant ascites
郑鸿 1陶莉 1杨新苗 1吴海霞1
作者信息
- 1. 复旦大学附属肿瘤医院闵行分院化疗科,上海200240
- 折叠
摘要
Abstract
Objective To evaluate the efficiency and safety of Endostar combined with chemotherapy and local hyperthermia on malignant ascites. Methods Fifty-three advanced cancer patients with malignant ascites were confirmed by histopathology or cytopathology. All the patients were divided into the treatment group (25 cases, Group A) and the control group (28 cases, Group B). Both groups were given chemotherapy (DDP40 ~60 mg) and local hyperthermia. Meanwhile the patients in Group A were treated with Endostar 60 mg dl ,d4. All the patients were given local hyperthermia twice a week (dl ,d4). The regimen was repeated every 7 days. The effect was evaluated after 2 cycles according to RESICT criteria,and Karnofsky scores was evaluated. Results The total effective rate of Group A was 76. 0% , while that of Group B was 57. 1 % . The total efficiency was significantly different ( P < 0. 05 ). Karnofsky scores of Group A was improved in 18 cases (72. 0% ) , and 16 cases of Group B(57. 1% ). The total efficiency was significantly different (P < 0. 05 ). For Group A, the occurrence rate of toxicities was low, which was mainly related with the chemotherapy agents. The regimen was well tolerable and generally did not give rise to serious side effects. Conclusions Intraperitoneal Endostatin combined with DDP and local hyperthermia results in a good response rate and improves Karnofsky scores in the patients with malignant ascites. The combined regimen was low toxic and tolerable. The regimen is worthy of clinic application and further research.关键词
肿瘤/药物疗法/水肿/腹腔/恩度/治疗应用/高温,治疗性Key words
neoplasms/drug therapy/ edema/ peritoneal cavity/ Endostar/therapeutic use/ hyperthermia, therapeutic分类
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郑鸿,陶莉,杨新苗,吴海霞..恩度加化疗联合局部热疗治疗恶性腹腔积液临床观察[J].实用肿瘤杂志,2012,27(5):496-498,3.
