西安交通大学学报（医学版）2012，Vol.33Issue(5)：576-582,7.
肝移植术与肝切除术治疗原发性肝癌的meta分析
Liver transplantation versus resection for treatment of hepatocellular carcinoma: A meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy of liver transplantation (OLT) and resection (RT) for hepatocellular carcinoma (HCC) with meta-analysis. Methods The literature on the therapeutic effect of OLT and RT on HCC was retrieved combined with manual retrieval from Pubmedi EMBASE, Ovid, ScienceDirect, Springerlink, EBSCO, CBM, China National Knowledge Infrastructure (CNKI), Wanfang Database, and Weipu Database published between 1990 and 2010 in China. RevMan 5.0 software was used for data analysis. Results According to the selection criteria, 9 clinical trials were selected finally. The combined results of meta-analysis with fixed effect model showed that the 1-year survival rate was similar (OR = 1.26, 95% CI 0.93 -1.17,P = 0.13);3-year survival rate in HCC patients was higher with OLT than with RT (OR = 1. 68, 95% CI 1.31-2.17, P<0.01)t 5-year survival rate was higher with OLT than with RT (OR=2.17. 95% CI 1.63-2.89, P<0.01); 5-year survival disease-free rate was higher with OLT than with RT (OR=5.07, 95% CI 3.27-7.86, P<0.01), and the recurrence rate of HCC was lower with OLT than with RT (OR=0.10, 95% CI 0.06-0.14, P<0.0l). Conclusion OLT and RT are both effective surgical methods for treating HCC, but OLT leads to a better prognosis in HCC than RT.关键词
肝细胞癌/肝移植/肝切除/生存率/复发率/meta分析Key words
hepatocellular carcinoma (HCC)/liver transplantation/liver resection/survival rate/recurrence rate/meta-analysis分类
医药卫生引用本文复制引用
许秋然,郑鑫,姚英民,杨威,刘青光..肝移植术与肝切除术治疗原发性肝癌的meta分析[J].西安交通大学学报（医学版）,2012,33(5):576-582,7.基金项目
国家自然科学基金资助项目(No.81072052/H1617) （No.81072052/H1617）
陕西省科技攻关项目(No.2010K01-128) （No.2010K01-128）
